Human μ opiate receptor

Opiate receptor binding sites in human brain.

Subclasses of opiate receptor binding sites in human brain membranes were investigated by means of competitive binding techniques. The experimental data were analyzed by use of a computerized non-linear regression curve fitting program. mu-, delta-and chi-types of opiate binding were found in 5 different regions of the brain. A more extensive analysis of the regional distribution of subclasses ...

Opiates Transdeactivate Chemokine Receptors: δ and μ Opiate Receptor–mediated Heterologous Desensitization

An intact chemotactic response is vital for leukocyte trafficking and host defense. Opiates are known to exert a number of immunomodulating effects in vitro and in vivo, and we sought to determine whether they were capable of inhibiting chemokine-induced directional migration of human leukocytes, and if so, to ascertain the mechanism involved. The endogenous opioid met-enkephalin induced monocy...

Opiate receptor revisited.

OUR identification of opiate receptors 34 yr ago seems distant. Today, receptors for drugs and neurotransmitters are taken for granted. Almost all receptors have been cloned, providing intimate understanding of signal transduction. Modern drug development uses robotics to screen millions of chemicals at dozens of receptors and their subtypes. By contrast, when we began our work, how drugs and n...

Src‐dependent phosphorylation of μ‐opioid receptor at Tyr336 modulates opiate withdrawal

Opiate withdrawal/negative reinforcement has been implicated as one of the mechanisms for the progression from impulsive to compulsive drug use. Increase in the intracellular cAMP level and protein kinase A (PKA) activities within the neurocircuitry of addiction has been a leading hypothesis for opiate addiction. This increase requires the phosphorylation of μ-opioid receptor (MOR) at Tyr336 by...

Novel Alternatively Spliced Variant of the Human Opiate Receptor Gene